Lieber Research Group

  • Home
  • Research
    • Overview
    • Nanomaterials
    • Nano-Bioelectronics
    • Brain Science
    • Image Gallery
  • People
    • Charles M. Lieber
    • Grad Students
    • Post Docs
    • Tech & Admin Staff
    • Former Group Members
    • Group News
  • Publications
  • News
  • Resources
    • Shared Resources
    • Facilities
      • Materials Synthesis
      • Assembly and Fabrication
      • Characterization
      • Biology
    • Lab Tour
    • Research Sponsors
    • Sitemap
  • Contact

The Lieber group is focused broadly on science and technology at the nanoscale, harnessing the unique physical properties of novel nanomaterials to push scientific boundaries in biology and medicine.

We are pushing the boundaries in design, synthesis, characterization and hierarchical assembly of nanoscale materials, with an emphasis on novel nanostructures and device arrays for use at the interface with biology and medicine. See Research page.

We are pioneering the interface between nanoelectronics and the life sciences, from sensors for real-time disease detection to development of novel cyborg cells and hybrid nanoelectronics-innervated tissues. See Research page.

We are focusing on a novel approach for integrating electronics within the brain and other areas of the nervous system, which involves non-invasive syringe delivery of neural network-like mesh electronics into targeted distinct brain regions. See Research page.

Nanomaterials
Nano-bioelectronics
Brain Science
  • Nanomaterials
  • Nano-bioelectronics
  • Brain Science

News & Highlights

  • Charles M. Lieber awarded the 2019 Welch Award in Chemistry
    Charles M. Lieber awarded the 2019 Welch Award in Chemistry

    The Welch Foundation announced the 2019 winners of the prestigious Robert A. Welch Award in Chemistry, which honors highly-respected and influential leaders in the fields of nanoscience and nanotechnology. Charles M. Lieber shares his award with A. Paul Alivisatos, who are recognized for their important research contributions which have had a significant, positive impact on humankind. Lieber has provided seminal concepts central to the bottom-up paradigm of nanoscience and has been a leader in the application of nanomaterials. Drs. Lieber and Alivisatos will be honored at the Welch Award Banquet on October 21st.

    Read More

  • Lieber and Patel introduce paradigm of precision electronic medicine as published in Nature Biotechnology
    Lieber and Patel introduce paradigm of precision electronic medicine as published in Nature Biotechnology

    The concept of “precision electronic medicine in the brain” is articulated for the first time as the vision for how neurotechnology can deliver personalized medicine to treat complex neurological and psychiatric disorders, as well as restore functions in degenerative diseases, trauma, and amputation. Neuron-like electronics could provide a way to stably map, track, and modulate the same individual neurons and neural circuits over extended time periods, unlocking new avenues for personalized therapy. This work addresses how to build an intimate and long-term stable interface between electronics and the constituent cells of the brain via tissue-like, high-resolution and large-scale neural probes. Previous advances have been featured in various news media; please see articles here.

    Read More

  • Lieber lab’s latest work on nanowire arrays for scalable intracellular recording published in Nature Nanotechnology
    Lieber lab’s latest work on nanowire arrays for scalable intracellular recording published in Nature Nanotechnology

    The article, titled “Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording,” describes the Lieber group's latest revolutionary approach to scalable intracellular recording by large arrays of nanowire transistors. This work represents a major step towards tackling the general problem of integrating ‘synthesized’ nanoscale building blocks into chip and wafer scale arrays, thereby addressing the long-standing challenge of scalable intracellular electrical recording and ultimately driving the development of advanced high-resolution brain-machine interfaces. Please see the various news media articles here.

    Read More

  • Lieber Lab’s latest work on chronic in-vivo retina recording ranked one of the Top Technical Advances in 2018 by The Scientist
    Lieber Lab’s latest work on chronic in-vivo retina recording ranked one of the Top Technical Advances in 2018 by The Scientist

    The Scientist is a professional magazine with reviews and highlights of the latest research in the life sciences and biotechnology. In the article ‘Top Technical Advances in 2018’ published on Dec. 24, 2018, The Scientist magazine summarizes this year’s most impressive scientific achievements, including work from the Lieber Lab that uses injectable mesh electronics for chronic recording of single-neuron activity in the mouse retina in vivo. Please see Science paper here.

    Read More

  • Visit our new mesh electronics resources website!
    Visit our new mesh electronics resources website!

    Syringe-injectable mesh electronics can integrate seamlessly with brain, retina and other tissues in living animals to yield an endogenous distribution of cells and to enable stable tracking of the same neurons and circuits over months to year periods, opening up exciting opportunities in neuroscience, bioengineering and medicine. Protocols, photomask designs for mesh fabrication, and printed circuit boards for input/output (I/O) interfaces as well as other information relating to injectable mesh electronics are now posted on our shared resources site. We hope these resources will be of value to researchers seeking to implement this unique technology in their work.

    Read More

  • Postdoctoral Positions
    Postdoctoral Positions

    Postdoctoral scientist openings at the interface between electronics and brain science are currently available with an emphasis on either novel probe development or applications of our novel technologies to behavior, cognitive and/or disease neuroscience. A background in neuroscience, nanoelectronics, tissue engineering or related fields, and a strong motivation to push the frontiers of science and technology, are important. Interested individuals are encouraged to contact Professor Lieber to explore these opportunities further.

Recent Publications

  • S.R. Patel and C.M. Lieber, “Precision electronic medicine in the brain,” Nat. Biotechnol. 37, 1007–1012 (2019).

    Read More

  • J.M. Lee, G. Hong, D. Lin, T.G. Schuhmann, A.T. Sullivan, R.D. Viveros, H.-G. Park and C.M. Lieber, "Nano-enabled direct contact interfacing of syringe-injectable mesh electronics," Nano Lett. 19, 5818−5826 (2019).

    Read More

  • Y. Zhao, S. You, A. Zhang, J.-H. Lee, J.L. Huang and C.M. Lieber, “Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording,” Nat. Nanotechnol. 14, 783-790 (2019).

    Read More

  • R.D. Viveros, T. Zhou, G. Hong, T.-M. Fu, H.Y.G. Lin and C.M. Lieber, “Advanced one- and two-dimensional mesh designs for injectable electronics,” Nano Lett. 19, 4180-4187 (2019).

    Read More

  • B. Tian and C.M. Lieber, "Nanowired bioelectric interfaces," Chem. Rev. 119, 9136−9152 (2019).

    Read More

  • G. Hong and C.M. Lieber, “Novel electrode technologies for neural recordings,” Nat. Rev. Neurosci. 20, 330-345 (2019).

    Read More

  • X. Yang, T. Zhou, T.J. Zwang, G. Hong, Y. Zhao, R.D. Viveros, T.-M. Fu, T. Gao and C.M. Lieber, “Bioinspired neuron-like electronics,” Nat. Mater. 18, 510-517 (2019).

    Read More

  • R. Wang, R.S. Deacon, J. Sun, J. Yao, C.M. Lieber and K. Ishibashi, “Gate tunable hole charge qubit formed in a Ge/Si nanowire double quantum dot coupled to microwave photons,” Nano Lett. 19, 1052-1060 (2019).

    Read More

  • T.G. Schuhmann, T. Zhou, G. Hong, J.M. Lee, T.-M. Fu, H.-G. Park and C.M. Lieber, “Syringe-injectable mesh electronics for stable chronic rodent electrophysiology,” J. Vis. Exp. 137, e58003 (2018).

    Read More

  • G. Hong, T.-M. Fu, M. Qian, R.D. Viveros, X. Yang, T. Zhou, J.M. Lee, H.-G. Park, J.R. Sanes and C.M. Lieber, “A method for single-neuron chronic recording from the retina in awake mice,” Science 360, 1447-1451 (2018).

    Read More

  • G. Hong, R.D. Viveros, T. Zwang, X. Yang and C.M. Lieber, “Tissue-like neural probes for understanding and modulating the brain,” Biochemistry 57, 3995-4004 (2018).

    Read More

Our Sponsors
Previous
  • Office of Naval Research

    http://www.onr.navy.mil/

  • Defense Advanced Research Projects Agency

    www.darpa.mil

  • Air Force Office of Scientific Research

    www.wpafb.af.mil

  • National Institutes of Health

    http://www.nih.gov/

  • MITRE

    http://www.mitre.org/

Next
Harvard University

Harvard University
12 Oxford Street, Cambridge, MA 02138
p: 617-496-3169 | f: 617-496-5442 | Contact Us | Login

©2019 Harvard University. Website design by Jackrabbit Design

  • Home
  • Research
  • People
  • Publications
  • News
  • Resources
  • Contact